6UYC

Crystal structure of TEAD2 bound to Compound 2

Summary for 6UYC

Entry DOI	10.2210/pdb6uyc/pdb
Descriptor	Transcriptional enhancer factor TEF-4, N-{5-[(E)-2-(4,4-difluorocyclohexyl)ethenyl]-6-methoxypyridin-3-yl}methanesulfonamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (4 entities in total)
Functional Keywords	tead, yap binding domain, transcription inhibitor, palmitoylation inhibitor, transcription-inhibitor complex, transcription/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	54221.20
Authors	Noland, C.L.,Holden, J.K.,Crawford, J.J.,Zbieg, J.R.,Cunningham, C.N. (deposition date: 2019-11-12, release date: 2020-06-24, Last modification date: 2023-10-11)
Primary citation	Holden, J.K.,Crawford, J.J.,Noland, C.L.,Schmidt, S.,Zbieg, J.R.,Lacap, J.A.,Zang, R.,Miller, G.M.,Zhang, Y.,Beroza, P.,Reja, R.,Lee, W.,Tom, J.Y.K.,Fong, R.,Steffek, M.,Clausen, S.,Hagenbeek, T.J.,Hu, T.,Zhou, Z.,Shen, H.C.,Cunningham, C.N. Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep, 31:107809-107809, 2020 Cited by PubMed: 32579935 DOI: 10.1016/j.celrep.2020.107809 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.658 Å)

Structure validation