6T5J

Structure of NUDT15 in complex with inhibitor TH1760

Summary for 6T5J

Entry DOI	10.2210/pdb6t5j/pdb
Descriptor	Probable 8-oxo-dGTP diphosphatase NUDT15, 6-[4-(1~{H}-indol-5-ylcarbonyl)piperazin-1-yl]sulfonyl-3~{H}-1,3-benzoxazol-2-one, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	nudix hydrolase, inhibitor, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	38291.02
Authors	Carter, M.,Rehling, D.,Desroses, M.,Zhang, S.M.,Hagenkort, A.,Valerie, N.C.K.,Helleday, T.,Stenmark, P. (deposition date: 2019-10-16, release date: 2020-07-29, Last modification date: 2024-01-24)
Primary citation	Zhang, S.M.,Desroses, M.,Hagenkort, A.,Valerie, N.C.K.,Rehling, D.,Carter, M.,Wallner, O.,Koolmeister, T.,Throup, A.,Jemth, A.S.,Almlof, I.,Loseva, O.,Lundback, T.,Axelsson, H.,Regmi, S.,Sarno, A.,Kramer, A.,Pudelko, L.,Brautigam, L.,Rasti, A.,Gottmann, M.,Wiita, E.,Kutzner, J.,Schaller, T.,Kalderen, C.,Cazares-Korner, A.,Page, B.D.G.,Krimpenfort, R.,Eshtad, S.,Altun, M.,Rudd, S.G.,Knapp, S.,Scobie, M.,Homan, E.J.,Berglund, U.W.,Stenmark, P.,Helleday, T. Development of a chemical probe against NUDT15. Nat.Chem.Biol., 16:1120-1128, 2020 Cited by PubMed: 32690945 DOI: 10.1038/s41589-020-0592-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation