6T5J

Structure of NUDT15 in complex with inhibitor TH1760

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000278	biological_process	mitotic cell cycle
A	0000302	biological_process	response to reactive oxygen species
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006195	biological_process	purine nucleotide catabolic process
A	0006203	biological_process	dGTP catabolic process
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042262	biological_process	DNA protection
A	0044715	molecular_function	8-oxo-dGDP phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	1901292	biological_process	nucleoside phosphate catabolic process
B	0000278	biological_process	mitotic cell cycle
B	0000302	biological_process	response to reactive oxygen species
B	0005515	molecular_function	protein binding
B	0005829	cellular_component	cytosol
B	0006195	biological_process	purine nucleotide catabolic process
B	0006203	biological_process	dGTP catabolic process
B	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B	0042178	biological_process	xenobiotic catabolic process
B	0042262	biological_process	DNA protection
B	0044715	molecular_function	8-oxo-dGDP phosphatase activity
B	0046872	molecular_function	metal ion binding
B	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	1901292	biological_process	nucleoside phosphate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue MKB A 201

Chain	Residue
A	GLY15
A	PHE135
A	GLY137
A	LEU138
A	HOH363
A	HOH376
B	PRO26
B	ARG27
A	VAL16
A	ARG34
A	GLN44
A	LEU45
A	GLY48
A	TYR90
A	TYR92
A	THR94

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 202

Chain	Residue
A	GLU63
A	GLU67
A	HOH310
A	HOH333
A	HOH354
A	HOH375

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 203

Chain	Residue
A	HOH330
A	HOH337
A	HOH366
A	HOH414
A	HOH490
B	HOH507

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CL A 204

Chain	Residue
A	ARG34
A	SER37
A	VAL38
B	ARG27
B	PHE149
B	HOH450

---

site_id	AC5
Number of Residues	17
Details	binding site for residue MKB B 201

Chain	Residue
A	ARG27
B	GLY15
B	VAL16
B	ARG34
B	GLN44
B	LEU45
B	GLY48
B	TYR90
B	TYR92
B	THR94
B	PHE135
B	GLY137
B	LEU138
B	HOH366
B	HOH374
B	HOH381
B	HOH490

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG B 202

Chain	Residue
B	GLU63
B	GLU67
B	HOH313
B	HOH332
B	HOH350
B	HOH394

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MG B 203

Chain	Residue
B	HOH302
B	HOH318
B	HOH327
B	HOH351
B	HOH491
B	HOH512

---

site_id	AC8
Number of Residues	6
Details	binding site for residue CL B 204

Chain	Residue
A	ARG27
A	PHE149
A	HOH446
B	ARG34
B	SER37
B	VAL38

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU63
A	GLU67
B	GLU63
B	GLU67

---