6T5J
Structure of NUDT15 in complex with inhibitor TH1760
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0005515 | molecular_function | protein binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006195 | biological_process | purine nucleotide catabolic process |
| A | 0006203 | biological_process | dGTP catabolic process |
| A | 0006950 | biological_process | response to stress |
| A | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| A | 0009217 | biological_process | purine deoxyribonucleoside triphosphate catabolic process |
| A | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| A | 0036217 | molecular_function | dGTP diphosphatase activity |
| A | 0042178 | biological_process | xenobiotic catabolic process |
| A | 0042262 | biological_process | DNA protection |
| A | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| A | 0047429 | molecular_function | nucleoside triphosphate diphosphatase activity |
| A | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| A | 0061136 | biological_process | regulation of proteasomal protein catabolic process |
| A | 0106405 | molecular_function | isoprenoid diphosphate phosphatase activity |
| A | 0120557 | molecular_function | farnesyl diphosphatase activity |
| A | 1901292 | biological_process | nucleoside phosphate catabolic process |
| B | 0000278 | biological_process | mitotic cell cycle |
| B | 0005515 | molecular_function | protein binding |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006195 | biological_process | purine nucleotide catabolic process |
| B | 0006203 | biological_process | dGTP catabolic process |
| B | 0006950 | biological_process | response to stress |
| B | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| B | 0009217 | biological_process | purine deoxyribonucleoside triphosphate catabolic process |
| B | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| B | 0036217 | molecular_function | dGTP diphosphatase activity |
| B | 0042178 | biological_process | xenobiotic catabolic process |
| B | 0042262 | biological_process | DNA protection |
| B | 0044715 | molecular_function | 8-oxo-dGDP phosphatase activity |
| B | 0047429 | molecular_function | nucleoside triphosphate diphosphatase activity |
| B | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| B | 0061136 | biological_process | regulation of proteasomal protein catabolic process |
| B | 0106405 | molecular_function | isoprenoid diphosphate phosphatase activity |
| B | 0120557 | molecular_function | farnesyl diphosphatase activity |
| B | 1901292 | biological_process | nucleoside phosphate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue MKB A 201 |
| Chain | Residue |
| A | GLY15 |
| A | PHE135 |
| A | GLY137 |
| A | LEU138 |
| A | HOH363 |
| A | HOH376 |
| B | PRO26 |
| B | ARG27 |
| A | VAL16 |
| A | ARG34 |
| A | GLN44 |
| A | LEU45 |
| A | GLY48 |
| A | TYR90 |
| A | TYR92 |
| A | THR94 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | GLU63 |
| A | GLU67 |
| A | HOH310 |
| A | HOH333 |
| A | HOH354 |
| A | HOH375 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 203 |
| Chain | Residue |
| A | HOH330 |
| A | HOH337 |
| A | HOH366 |
| A | HOH414 |
| A | HOH490 |
| B | HOH507 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 204 |
| Chain | Residue |
| A | ARG34 |
| A | SER37 |
| A | VAL38 |
| B | ARG27 |
| B | PHE149 |
| B | HOH450 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue MKB B 201 |
| Chain | Residue |
| A | ARG27 |
| B | GLY15 |
| B | VAL16 |
| B | ARG34 |
| B | GLN44 |
| B | LEU45 |
| B | GLY48 |
| B | TYR90 |
| B | TYR92 |
| B | THR94 |
| B | PHE135 |
| B | GLY137 |
| B | LEU138 |
| B | HOH366 |
| B | HOH374 |
| B | HOH381 |
| B | HOH490 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | GLU63 |
| B | GLU67 |
| B | HOH313 |
| B | HOH332 |
| B | HOH350 |
| B | HOH394 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 203 |
| Chain | Residue |
| B | HOH302 |
| B | HOH318 |
| B | HOH327 |
| B | HOH351 |
| B | HOH491 |
| B | HOH512 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue CL B 204 |
| Chain | Residue |
| A | ARG27 |
| A | PHE149 |
| A | HOH446 |
| B | ARG34 |
| B | SER37 |
| B | VAL38 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Motif: {"description":"Nudix box"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26238318","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BON","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"38944687","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7R0D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26238318","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38944687","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7R0D","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
