6SBV
X-ray Structure of Human LDH-A with an Allosteric Inhibitor (Compound 7)
Summary for 6SBV
Entry DOI | 10.2210/pdb6sbv/pdb |
Related | 6SBU |
Descriptor | L-lactate dehydrogenase A chain, ~{N}-[3-[(7-nitrodibenzofuran-2-yl)sulfonylamino]phenyl]-1-oxidanyl-cyclopropane-1-carboxamide (3 entities in total) |
Functional Keywords | ldha, oxidoreductase, oxidoreductase inhibitor, allosteric inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 8 |
Total formula weight | 297023.82 |
Authors | Friberg, A.,Puetter, V.,Nguyen, D.,Rehwinkel, H. (deposition date: 2019-07-22, release date: 2020-06-10, Last modification date: 2024-01-24) |
Primary citation | Friberg, A.,Rehwinkel, H.,Nguyen, D.,Putter, V.,Quanz, M.,Weiske, J.,Eberspacher, U.,Heisler, I.,Langer, G. Structural Evidence for Isoform-Selective Allosteric Inhibition of Lactate Dehydrogenase A. Acs Omega, 5:13034-13041, 2020 Cited by PubMed: 32548488DOI: 10.1021/acsomega.0c00715 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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