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6SBV

X-ray Structure of Human LDH-A with an Allosteric Inhibitor (Compound 7)

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004459molecular_functionL-lactate dehydrogenase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006089biological_processlactate metabolic process
A0006090biological_processpyruvate metabolic process
A0006096biological_processglycolytic process
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019752biological_processcarboxylic acid metabolic process
A0042802molecular_functionidentical protein binding
A0045296molecular_functioncadherin binding
A0070062cellular_componentextracellular exosome
A1990204cellular_componentoxidoreductase complex
B0003824molecular_functioncatalytic activity
B0004459molecular_functionL-lactate dehydrogenase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006089biological_processlactate metabolic process
B0006090biological_processpyruvate metabolic process
B0006096biological_processglycolytic process
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B0019752biological_processcarboxylic acid metabolic process
B0042802molecular_functionidentical protein binding
B0045296molecular_functioncadherin binding
B0070062cellular_componentextracellular exosome
B1990204cellular_componentoxidoreductase complex
C0003824molecular_functioncatalytic activity
C0004459molecular_functionL-lactate dehydrogenase activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006089biological_processlactate metabolic process
C0006090biological_processpyruvate metabolic process
C0006096biological_processglycolytic process
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C0019752biological_processcarboxylic acid metabolic process
C0042802molecular_functionidentical protein binding
C0045296molecular_functioncadherin binding
C0070062cellular_componentextracellular exosome
C1990204cellular_componentoxidoreductase complex
D0003824molecular_functioncatalytic activity
D0004459molecular_functionL-lactate dehydrogenase activity
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006089biological_processlactate metabolic process
D0006090biological_processpyruvate metabolic process
D0006096biological_processglycolytic process
D0016020cellular_componentmembrane
D0016491molecular_functionoxidoreductase activity
D0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D0019752biological_processcarboxylic acid metabolic process
D0042802molecular_functionidentical protein binding
D0045296molecular_functioncadherin binding
D0070062cellular_componentextracellular exosome
D1990204cellular_componentoxidoreductase complex
E0003824molecular_functioncatalytic activity
E0004459molecular_functionL-lactate dehydrogenase activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005829cellular_componentcytosol
E0006089biological_processlactate metabolic process
E0006090biological_processpyruvate metabolic process
E0006096biological_processglycolytic process
E0016020cellular_componentmembrane
E0016491molecular_functionoxidoreductase activity
E0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E0019752biological_processcarboxylic acid metabolic process
E0042802molecular_functionidentical protein binding
E0045296molecular_functioncadherin binding
E0070062cellular_componentextracellular exosome
E1990204cellular_componentoxidoreductase complex
F0003824molecular_functioncatalytic activity
F0004459molecular_functionL-lactate dehydrogenase activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005829cellular_componentcytosol
F0006089biological_processlactate metabolic process
F0006090biological_processpyruvate metabolic process
F0006096biological_processglycolytic process
F0016020cellular_componentmembrane
F0016491molecular_functionoxidoreductase activity
F0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F0019752biological_processcarboxylic acid metabolic process
F0042802molecular_functionidentical protein binding
F0045296molecular_functioncadherin binding
F0070062cellular_componentextracellular exosome
F1990204cellular_componentoxidoreductase complex
G0003824molecular_functioncatalytic activity
G0004459molecular_functionL-lactate dehydrogenase activity
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005829cellular_componentcytosol
G0006089biological_processlactate metabolic process
G0006090biological_processpyruvate metabolic process
G0006096biological_processglycolytic process
G0016020cellular_componentmembrane
G0016491molecular_functionoxidoreductase activity
G0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G0019752biological_processcarboxylic acid metabolic process
G0042802molecular_functionidentical protein binding
G0045296molecular_functioncadherin binding
G0070062cellular_componentextracellular exosome
G1990204cellular_componentoxidoreductase complex
H0003824molecular_functioncatalytic activity
H0004459molecular_functionL-lactate dehydrogenase activity
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005739cellular_componentmitochondrion
H0005829cellular_componentcytosol
H0006089biological_processlactate metabolic process
H0006090biological_processpyruvate metabolic process
H0006096biological_processglycolytic process
H0016020cellular_componentmembrane
H0016491molecular_functionoxidoreductase activity
H0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H0019752biological_processcarboxylic acid metabolic process
H0042802molecular_functionidentical protein binding
H0045296molecular_functioncadherin binding
H0070062cellular_componentextracellular exosome
H1990204cellular_componentoxidoreductase complex
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue L5K A 1001
ChainResidue
AARG169
BHIS67
BLEU70
BTHR74
BPRO75
BLYS76
BILE77
BHOH1110
ATYR172
ALEU173
AGLU176
AVAL180
AGLN233
ASER237
AHOH1116
BGLN66

site_idAC2
Number of Residues17
Detailsbinding site for residue L5K B 1001
ChainResidue
AGLN66
AHIS67
ALEU70
ATHR74
APRO75
ALYS76
AILE77
AHOH1143
BARG169
BTYR172
BLEU173
BGLU176
BGLY179
BVAL180
BGLN233
BSER237
BHOH1104

site_idAC3
Number of Residues14
Detailsbinding site for residue L5K C 1001
ChainResidue
CARG169
CTYR172
CLEU173
CGLU176
CVAL180
CGLN233
CSER237
CHOH1112
DGLN66
DHIS67
DLEU70
DTHR74
DPRO75
DILE77

site_idAC4
Number of Residues15
Detailsbinding site for residue L5K D 1001
ChainResidue
CGLN66
CHIS67
CLEU70
CTHR74
CPRO75
CLYS76
CILE77
DARG169
DTYR172
DLEU173
DGLU176
DVAL180
DGLN233
DSER237
DHOH1114

site_idAC5
Number of Residues16
Detailsbinding site for residue L5K E 1001
ChainResidue
EARG169
ETYR172
ELEU173
EGLU176
EVAL180
EGLN233
ESER237
EHOH1109
EHOH1139
FGLN66
FHIS67
FLEU70
FTHR74
FPRO75
FLYS76
FILE77

site_idAC6
Number of Residues16
Detailsbinding site for residue L5K F 1001
ChainResidue
EGLN66
EHIS67
ELEU70
ETHR74
EPRO75
ELYS76
EILE77
FARG169
FTYR172
FLEU173
FGLU176
FGLY179
FVAL180
FSER237
FHOH1104
FHOH1137

site_idAC7
Number of Residues14
Detailsbinding site for residue L5K G 1001
ChainResidue
GGLN233
GSER237
GHOH1101
HGLN66
HHIS67
HLEU70
HTHR74
HPRO75
HILE77
EHOH1128
GARG169
GTYR172
GLEU173
GGLU176

site_idAC8
Number of Residues14
Detailsbinding site for residue L5K H 1001
ChainResidue
GGLN66
GHIS67
GLEU70
GTHR74
GPRO75
GILE77
HARG169
HTYR172
HLEU173
HGLU176
HVAL180
HGLN233
HSER237
HHOH1101

Functional Information from PROSITE/UniProt
site_idPS00064
Number of Residues7
DetailsL_LDH L-lactate dehydrogenase active site. LGEHGDS
ChainResidueDetails
ALEU190-SER196

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AHIS193
BHIS193
CHIS193
DHIS193
EHIS193
FHIS193
GHIS193
HHIS193

site_idSWS_FT_FI2
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:11276087
ChainResidueDetails
EGLY29
EARG99
FGLY29
FARG99
GGLY29
GARG99
HGLY29
HARG99
AARG99
BGLY29
BARG99
CGLY29
CARG99
DGLY29
DARG99
AGLY29

site_idSWS_FT_FI3
Number of Residues32
DetailsBINDING:
ChainResidueDetails
CARG106
CASN138
CARG169
CTHR248
DARG106
DASN138
DARG169
DTHR248
EARG106
EASN138
EARG169
ETHR248
FARG106
FASN138
FARG169
FTHR248
GARG106
GASN138
GARG169
GTHR248
HARG106
HASN138
HARG169
HTHR248
AASN138
AARG169
ATHR248
BARG106
BASN138
BARG169
BTHR248
AARG106

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.10, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895
ChainResidueDetails
EALA2
FALA2
GALA2
HALA2
AALA2
BALA2
CALA2
DALA2

site_idSWS_FT_FI5
Number of Residues24
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151
ChainResidueDetails
CLYS318
DLYS5
DLYS118
DLYS318
ELYS5
ELYS118
ELYS318
FLYS5
FLYS118
FLYS318
GLYS5
GLYS118
GLYS318
HLYS5
HLYS118
HLYS318
ALYS118
ALYS318
BLYS5
BLYS118
BLYS318
CLYS5
CLYS118
ALYS5

site_idSWS_FT_FI6
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332
ChainResidueDetails
DTYR10
ETYR10
FTYR10
GTYR10
HTYR10
ATYR10
BTYR10
CTYR10

site_idSWS_FT_FI7
Number of Residues24
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
CLYS126
DLYS14
DLYS81
DLYS126
ELYS14
ELYS81
ELYS126
FLYS14
FLYS81
FLYS126
GLYS14
GLYS81
GLYS126
HLYS14
HLYS81
HLYS126
ALYS81
ALYS126
BLYS14
BLYS81
BLYS126
CLYS14
CLYS81
ALYS14

site_idSWS_FT_FI8
Number of Residues8
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
DTHR18
ETHR18
FTHR18
GTHR18
HTHR18
ATHR18
BTHR18
CTHR18

site_idSWS_FT_FI9
Number of Residues8
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS57
CLYS57
DLYS57
ELYS57
FLYS57
GLYS57
HLYS57
ALYS57

site_idSWS_FT_FI10
Number of Residues24
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P06151
ChainResidueDetails
CLYS243
DLYS224
DLYS232
DLYS243
ELYS224
ELYS232
ELYS243
FLYS224
FLYS232
FLYS243
GLYS224
GLYS232
GLYS243
HLYS224
HLYS232
HLYS243
ALYS232
ALYS243
BLYS224
BLYS232
BLYS243
CLYS224
CLYS232
ALYS224

site_idSWS_FT_FI11
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P06151
ChainResidueDetails
ATYR239
BTYR239
CTYR239
DTYR239
ETYR239
FTYR239
GTYR239
HTYR239

site_idSWS_FT_FI12
Number of Residues16
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P04642
ChainResidueDetails
ETHR309
ETHR322
FTHR309
FTHR322
GTHR309
GTHR322
HTHR309
HTHR322
ATHR309
ATHR322
BTHR309
BTHR322
CTHR309
CTHR322
DTHR309
DTHR322

site_idSWS_FT_FI13
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER310
BSER310
CSER310
DSER310
ESER310
FSER310
GSER310
HSER310

site_idSWS_FT_FI14
Number of Residues16
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733
ChainResidueDetails
ELYS57
FLYS57
GLYS57
HLYS57
ALYS57
BLYS57
CLYS57
DLYS57

221051

PDB entries from 2024-06-12

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