6RUV
Structure of the SCIN stabilized C3bBb convertase bound to Properdin and a the non-inhibitory nanobody hFPNb1
Summary for 6RUV
Entry DOI | 10.2210/pdb6ruv/pdb |
Descriptor | Nanobody hFPNb1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose, ... (12 entities in total) |
Functional Keywords | innate immunity, complement, proteolytic enzyme, regulator, nanobody, immune system |
Biological source | Lama glama More |
Total number of polymer chains | 14 |
Total formula weight | 610525.62 |
Authors | Pedersen, D.V.,Andersen, G.R. (deposition date: 2019-05-29, release date: 2019-08-21, Last modification date: 2024-01-24) |
Primary citation | Pedersen, D.V.,Gadeberg, T.A.F.,Thomas, C.,Wang, Y.,Joram, N.,Jensen, R.K.,Mazarakis, S.M.M.,Revel, M.,El Sissy, C.,Petersen, S.V.,Lindorff-Larsen, K.,Thiel, S.,Laursen, N.S.,Fremeaux-Bacchi, V.,Andersen, G.R. Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System. Front Immunol, 10:2007-2007, 2019 Cited by PubMed: 31507604DOI: 10.3389/fimmu.2019.02007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (6.15 Å) |
Structure validation
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