6P50
Crystal Structure of a Complex of human IL-7Ralpha with an anti-IL-7Ralpha Fab 4A10
Summary for 6P50
Entry DOI | 10.2210/pdb6p50/pdb |
Descriptor | Interleukin-7 receptor subunit alpha, anti-IL-7R 4A10 Fab heavy chain, anti-IL-7R 4A10 Fab light chain, ... (4 entities in total) |
Functional Keywords | interleukin-7 receptor extracellular dohmain, antibody 4a10 fab fragment, protein polymer, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 73878.69 |
Authors | Walsh, S.T.R.,Kashi, L.,Kohnhorst, C.L. (deposition date: 2019-05-29, release date: 2019-09-04, Last modification date: 2023-10-11) |
Primary citation | Hixon, J.A.,Andrews, C.,Kashi, L.,Kohnhorst, C.L.,Senkevitch, E.,Czarra, K.,Barata, J.T.,Li, W.,Schneider, J.P.,Walsh, S.T.R.,Durum, S.K. New anti-IL-7R alpha monoclonal antibodies show efficacy against T cell acute lymphoblastic leukemia in pre-clinical models. Leukemia, 34:35-49, 2020 Cited by PubMed: 31439943DOI: 10.1038/s41375-019-0531-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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