6M8P
Human ERAP1 bound to phosphinic pseudotripeptide inhibitor DG013
This is a non-PDB format compatible entry.
Summary for 6M8P
Entry DOI | 10.2210/pdb6m8p/pdb |
Descriptor | Endoplasmic reticulum aminopeptidase 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (6 entities in total) |
Functional Keywords | inhibitor, aminopeptidase, antigen processing, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 22 |
Total formula weight | 2338352.31 |
Authors | Maben, Z.,Stern, L.J. (deposition date: 2018-08-22, release date: 2019-12-18, Last modification date: 2023-10-11) |
Primary citation | Maben, Z.,Arya, R.,Georgiadis, D.,Stratikos, E.,Stern, L.J. Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism. Nat Commun, 12:5302-5302, 2021 Cited by PubMed: 34489420DOI: 10.1038/s41467-021-25564-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.31 Å) |
Structure validation
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