6LVM
Crystal structure of FGFR3 in complex with pyrimidine derivative
Summary for 6LVM
Entry DOI | 10.2210/pdb6lvm/pdb |
Related | 6LVK 6LVL |
Descriptor | Fibroblast growth factor receptor 3, 2-[[5-[2-(3,5-dimethoxyphenyl)ethyl]-2-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]pyrimidin-4-yl]amino]-N-ethyl-benzenesulfonamide (3 entities in total) |
Functional Keywords | protein kinase, signaling protein, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36409.68 |
Authors | Echizen, Y.,Tateishi, Y.,Amano, Y. (deposition date: 2020-02-04, release date: 2020-04-08, Last modification date: 2023-11-29) |
Primary citation | Kuriwaki, I.,Kameda, M.,Hisamichi, H.,Kikuchi, S.,Iikubo, K.,Kawamoto, Y.,Moritomo, H.,Kondoh, Y.,Amano, Y.,Tateishi, Y.,Echizen, Y.,Iwai, Y.,Noda, A.,Tomiyama, H.,Suzuki, T.,Hirano, M. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg.Med.Chem., 28:115453-115453, 2020 Cited by PubMed: 32278710DOI: 10.1016/j.bmc.2020.115453 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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