6HN5
Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part
Summary for 6HN5
Entry DOI | 10.2210/pdb6hn5/pdb |
EMDB information | 0247 |
Descriptor | Insulin, Insulin receptor,General control protein GCN4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | insulin, insulin receptor ectodomain, signal transduction, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 221689.35 |
Authors | Weis, F.,Menting, J.G.,Margetts, M.B.,Chan, S.J.,Xu, Y.,Tennagels, N.,Wohlfart, P.,Langer, T.,Mueller, C.W.,Dreyer, M.K.,Lawrence, M.C. (deposition date: 2018-09-14, release date: 2018-11-21, Last modification date: 2022-03-30) |
Primary citation | Weis, F.,Menting, J.G.,Margetts, M.B.,Chan, S.J.,Xu, Y.,Tennagels, N.,Wohlfart, P.,Langer, T.,Muller, C.W.,Dreyer, M.K.,Lawrence, M.C. The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9:4420-4420, 2018 Cited by PubMed: 30356040DOI: 10.1038/s41467-018-06826-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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