6GZY
HOIP-fragment5 complex
Summary for 6GZY
Entry DOI | 10.2210/pdb6gzy/pdb |
Descriptor | E3 ubiquitin-protein ligase RNF31, methyl 4-[(2-oxidanylidene-1,5,6,7-tetrahydrocyclopenta[b]pyridin-3-yl)carbonylamino]butanoate, ZINC ION, ... (8 entities in total) |
Functional Keywords | ubiquitin ligase, e3, inhibitor complex, ligase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 52396.06 |
Authors | Johansson, H.,Tsai, Y.C.I.,Fantom, K.,Chung, C.W.,Martino, L.,House, D.,Rittinger, K. (deposition date: 2018-07-05, release date: 2019-01-30, Last modification date: 2024-01-17) |
Primary citation | Johansson, H.,Isabella Tsai, Y.C.,Fantom, K.,Chung, C.W.,Kumper, S.,Martino, L.,Thomas, D.A.,Eberl, H.C.,Muelbaier, M.,House, D.,Rittinger, K. Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J. Am. Chem. Soc., 141:2703-2712, 2019 Cited by PubMed: 30657686DOI: 10.1021/jacs.8b13193 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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