6GFF
Structure of GARP (LRRC32) in complex with latent TGF-beta1 and MHG-8 Fab
Summary for 6GFF
Entry DOI | 10.2210/pdb6gff/pdb |
Descriptor | Transforming growth factor beta-1, Leucine-rich repeat-containing protein 32, MHG-8 Fab light chain, ... (8 entities in total) |
Functional Keywords | garp, tgf-b1, activation, treg, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 14 |
Total formula weight | 398360.92 |
Authors | Merceron, R.,Lienart, S.,Vanderaa, C.,Colau, D.,Stockis, J.,Van Der Woning, B.,De Haard, H.,Saunders, M.,Coulie, P.G.,Savvides, S.N.,Lucas, S. (deposition date: 2018-04-30, release date: 2018-11-07, Last modification date: 2020-07-29) |
Primary citation | Lienart, S.,Merceron, R.,Vanderaa, C.,Lambert, F.,Colau, D.,Stockis, J.,van der Woning, B.,De Haard, H.,Saunders, M.,Coulie, P.G.,Savvides, S.N.,Lucas, S. Structural basis of latent TGF-beta 1 presentation and activation by GARP on human regulatory T cells. Science, 362:952-956, 2018 Cited by PubMed: 30361387DOI: 10.1126/science.aau2909 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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