6FM4
The crystal structure of S. aureus Gyrase complex with ID-130 and DNA
Summary for 6FM4
Entry DOI | 10.2210/pdb6fm4/pdb |
Descriptor | DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit A, DNA (5'-5UA*D(P*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), DNA (5'-5UA*D(P*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*C)-3'), ... (7 entities in total) |
Functional Keywords | nbtis, bacterial topoisomerase, gyrase, isomerase |
Biological source | Staphylococcus aureus (strain N315) More |
Total number of polymer chains | 4 |
Total formula weight | 168689.10 |
Authors | Ombrato, R.,Garofalo, B.,Mangano, G.,Mancini, F. (deposition date: 2018-01-30, release date: 2019-07-10, Last modification date: 2024-01-17) |
Primary citation | Magaro, G.,Prati, F.,Garofalo, B.,Corso, G.,Furlotti, G.,Apicella, C.,Mangano, G.,D'Atanasio, N.,Robinson, D.,Di Giorgio, F.P.,Ombrato, R. Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens. J.Med.Chem., 62:7445-7472, 2019 Cited by PubMed: 31276392DOI: 10.1021/acs.jmedchem.9b00394 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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