6FM4

The crystal structure of S. aureus Gyrase complex with ID-130 and DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006259	biological_process	DNA metabolic process
B	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006259	biological_process	DNA metabolic process
D	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue DU5 E 103

Chain	Residue
B	ALA1068
F	DC11
B	MET1075
B	ASP1083
B	MET1121
D	ASP1083
D	MET1121
E	DG10
E	DC11
F	DG10

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Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. LVEGDSAGG

Chain	Residue	Details
B	LEU433-GLY441

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01898

Chain	Residue	Details
B	GLU435
B	ASP508
B	ASP510
D	GLU435
D	ASP508
D	ASP510

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site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000255|HAMAP-Rule:MF_01898

Chain	Residue	Details
B	LYS460
B	ASN463
D	LYS460
D	ASN463

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site_id	SWS_FT_FI3
Number of Residues	2
Details	ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|HAMAP-Rule:MF_01897

Chain	Residue	Details
B	PHE1123
D	PHE1123

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