6FM4
The crystal structure of S. aureus Gyrase complex with ID-130 and DNA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, D | DNA gyrase subunit B,DNA gyrase subunit B,DNA gyrase subunit A | polymer | 692 | 78109.0 | 2 | UniProt (P66937) UniProt (Q99XG5) Pfam (PF01751) Pfam (PF00986) Pfam (PF00521) In PDB | Staphylococcus aureus (strain N315) | |
2 | E | DNA (5'-5UA*D(P*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3') | polymer | 19 | 5822.7 | 1 | synthetic construct | ||
3 | F | DNA (5'-5UA*D(P*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*C)-3') | polymer | 18 | 5518.6 | 1 | synthetic construct | ||
4 | B, E, F | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
5 | E, F | 5'-O-CARBOXY-2'-DEOXYADENOSINE | non-polymer | 295.3 | 2 | Chemie (5UA) | |||
6 | E | ~{N}-[3-(4-isoquinolin-1-ylpiperazin-1-yl)propyl]benzamide | non-polymer | 374.5 | 1 | Chemie (DU5) | |||
7 | water | water | 18.0 | 62 | Chemie (HOH) |
Sequence modifications
B, D: 409 - 543 (UniProt: P66937)
B, D: 580 - 1001 (UniProt: P66937)
B, D: 1002 - 1491 (UniProt: Q99XG5)
PDB | External Database | Details |
---|---|---|
Met 409 | Leu 409 | conflict |
PDB | External Database | Details |
---|---|---|
Thr 544 | - | linker |
Gly 545 | - | linker |
PDB | External Database | Details |
---|---|---|
Phe 1123 | Tyr 123 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 167559.3 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1129.8 | |
All* | Total formula weight | 168689.1 |