6EY7

Human cytomegalovirus terminase nuclease domain, Mn soaked, inhibitor bound

Summary for 6EY7

• Entry DOI: 10.2210/pdb6ey7/pdb
• Descriptor: UL89 HCMV terminase, MANGANESE (II) ION, 4-[(4-fluorophenyl)methyl-methyl-amino]-2,4-bis(oxidanylidene)butanoic acid, ... (5 entities in total)
• Functional Keywords: cytomegalovirus, ul89, terminase, inhibitors, drug design, raltegravir, viral protein
• Biological source: Human herpesvirus 5 strain AD169
• Total number of polymer chains: 4
• Total formula weight: 128869.29

Authors

Bongarzone, S.,Nadal, M.,Kaczmarska, Z.,Machon, C.,Alvarez, M.,Albericio, F.,Coll, M. (deposition date: 2017-11-10, release date: 2018-10-03, Last modification date: 2024-01-17)

• Primary citation: Bongarzone, S.,Nadal, M.,Kaczmarska, Z.,Machon, C.,Alvarez, M.,Albericio, F.,Coll, M.; Structure-Driven Discovery of alpha , gamma-Diketoacid Inhibitors Against UL89 Herpesvirus Terminase.; Acs Omega, 3:8497-8505, 2018; PubMed: 31458978; DOI: 10.1021/acsomega.8b01472

Experimental method

X-RAY DIFFRACTION (2.9 Å)