6EU5
Leishmania major N-myristoyltransferase with bound myristoyl-CoA and inhibitor
Summary for 6EU5
Entry DOI | 10.2210/pdb6eu5/pdb |
Related | 2WSA |
Descriptor | Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 4-[3-[(8~{a}~{R})-3,4,6,7,8,8~{a}-hexahydro-1~{H}-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-bis(chloranyl)-~{N}-methyl-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide, ... (4 entities in total) |
Functional Keywords | n-myristoyltransferase, selective inhibitor, parasite, transferase |
Biological source | Leishmania major |
Total number of polymer chains | 1 |
Total formula weight | 52005.65 |
Authors | Brenk, R.,Kehrein, J.,Kersten, C. (deposition date: 2017-10-27, release date: 2019-02-06, Last modification date: 2024-01-17) |
Primary citation | Kersten, C.,Fleischer, E.,Kehrein, J.,Borek, C.,Jaenicke, E.,Sotriffer, C.,Brenk, R. How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System. J.Med.Chem., 2019 Cited by PubMed: 31423787DOI: 10.1021/acs.jmedchem.9b00586 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49608302465 Å) |
Structure validation
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