6EU5

Leishmania major N-myristoyltransferase with bound myristoyl-CoA and inhibitor

Summary for 6EU5

Entry DOI	10.2210/pdb6eu5/pdb
Related	2WSA
Descriptor	Glycylpeptide N-tetradecanoyltransferase, TETRADECANOYL-COA, 4-[3-[(8~{a}~{R})-3,4,6,7,8,8~{a}-hexahydro-1~{H}-pyrrolo[1,2-a]pyrazin-2-yl]propyl]-2,6-bis(chloranyl)-~{N}-methyl-~{N}-(1,3,5-trimethylpyrazol-4-yl)benzenesulfonamide, ... (4 entities in total)
Functional Keywords	n-myristoyltransferase, selective inhibitor, parasite, transferase
Biological source	Leishmania major
Total number of polymer chains	1
Total formula weight	52005.65
Authors	Brenk, R.,Kehrein, J.,Kersten, C. (deposition date: 2017-10-27, release date: 2019-02-06, Last modification date: 2024-01-17)
Primary citation	Kersten, C.,Fleischer, E.,Kehrein, J.,Borek, C.,Jaenicke, E.,Sotriffer, C.,Brenk, R. How To Design Selective Ligands for Highly Conserved Binding Sites: A Case Study UsingN-Myristoyltransferases as a Model System. J.Med.Chem., 2019 Cited by PubMed: 31423787 DOI: 10.1021/acs.jmedchem.9b00586 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.49608302465 Å)

Structure validation