6B20

Crystal structure of a complex between G protein beta gamma dimer and an inhibitory Nanobody regulator

Summary for 6B20

Entry DOI	10.2210/pdb6b20/pdb
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, Nanobody against G protein beta gamma dimer, ... (6 entities in total)
Functional Keywords	beta propeller, g protein, g protein coupled receptor-signaling, signaling protein
Biological source	Bos taurus More
Total number of polymer chains	6
Total formula weight	113232.44
Authors	Gulati, S.,Kiser, P.D.,Palczewski, K. (deposition date: 2017-09-19, release date: 2018-05-30, Last modification date: 2023-10-04)
Primary citation	Gulati, S.,Jin, H.,Masuho, I.,Orban, T.,Cai, Y.,Pardon, E.,Martemyanov, K.A.,Kiser, P.D.,Stewart, P.L.,Ford, C.P.,Steyaert, J.,Palczewski, K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor. Nat Commun, 9:1996-1996, 2018 Cited by PubMed: 29777099 DOI: 10.1038/s41467-018-04432-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.34 Å)

Structure validation