6B0F
ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH LSZ102
Summary for 6B0F
Entry DOI | 10.2210/pdb6b0f/pdb |
Descriptor | Estrogen receptor, LSZ102, GLYCEROL, ... (4 entities in total) |
Functional Keywords | nuclear receptor, hormone receptor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 59012.96 |
Authors | Kirby, C.A.,Baird, J. (deposition date: 2017-09-14, release date: 2018-04-04, Last modification date: 2024-04-03) |
Primary citation | Tria, G.S.,Abrams, T.,Baird, J.,Burks, H.E.,Firestone, B.,Gaither, L.A.,Hamann, L.G.,He, G.,Kirby, C.A.,Kim, S.,Lombardo, F.,Macchi, K.J.,McDonnell, D.P.,Mishina, Y.,Norris, J.D.,Nunez, J.,Springer, C.,Sun, Y.,Thomsen, N.M.,Wang, C.,Wang, J.,Yu, B.,Tiong-Yip, C.L.,Peukert, S. Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer. J. Med. Chem., 61:2837-2864, 2018 Cited by PubMed: 29562737DOI: 10.1021/acs.jmedchem.7b01682 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.86 Å) |
Structure validation
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