6ACB
Crystal structure of PDE5 in complex with inhibitor LW1805
Summary for 6ACB
Entry DOI | 10.2210/pdb6acb/pdb |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, SULFATE ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | pde5 in complex with inhibitor lw1805, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 38535.94 |
Authors | Wu, D.,Huang, Y.D.,Huang, Y.Y.,Luo, H.B. (deposition date: 2018-07-26, release date: 2018-09-19, Last modification date: 2023-11-22) |
Primary citation | Wu, D.,Huang, Y.,Chen, Y.,Huang, Y.Y.,Geng, H.,Zhang, T.,Zhang, C.,Li, Z.,Guo, L.,Chen, J.,Luo, H.B. Optimization of Chromeno[2,3- c]pyrrol-9(2 H)-ones as Highly Potent, Selective, and Orally Bioavailable PDE5 Inhibitors: Structure-Activity Relationship, X-ray Crystal Structure, and Pharmacodynamic Effect on Pulmonary Arterial Hypertension. J. Med. Chem., 61:8468-8473, 2018 Cited by PubMed: 30148362DOI: 10.1021/acs.jmedchem.8b01209 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
Download full validation report