5ZMD
Crystal structure of FTO in complex with m6dA modified ssDNA
Summary for 5ZMD
Entry DOI | 10.2210/pdb5zmd/pdb |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO, DNA (5'-D(P*TP*CP*TP*(6MA)P*TP*AP*TP*CP*G)-3'), MANGANESE (II) ION, ... (5 entities in total) |
Functional Keywords | rna demetheylase fto, m6a, substrate preference, rna binding protein, oxidoreductase-dna complex, oxidoreductase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 224936.28 |
Authors | |
Primary citation | Zhang, X.,Wei, L.H.,Wang, Y.,Xiao, Y.,Liu, J.,Zhang, W.,Yan, N.,Amu, G.,Tang, X.,Zhang, L.,Jia, G. Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substrates. Proc. Natl. Acad. Sci. U.S.A., 116:2919-2924, 2019 Cited by PubMed: 30718435DOI: 10.1073/pnas.1820574116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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