5ZMC

Structural Basis for Reactivation of -146C>T Mutant TERT Promoter by cooperative binding of p52 and ETS1/2

5ZMC の概要

• エントリーDOI: 10.2210/pdb5zmc/pdb
• 分子名称: DNA (5'-D(P*CP*GP*GP*GP*GP*AP*CP*CP*CP*GP*GP*AP*AP*GP*GP*G)-3'), DNA (5'-D(P*GP*CP*CP*CP*TP*TP*CP*CP*GP*GP*GP*TP*CP*CP*CP*C)-3'), Protein C-ets-1, ... (4 entities in total)
• 機能のキーワード: ets1, p52, transcription factor, transcription, -146c>t mutant tert promoter activation, transcription-dna complex, transcription/dna
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 56082.24

構造登録者

Xu, X.,Bharath, S.R.,Song, H. (登録日: 2018-04-02, 公開日: 2018-09-19, 最終更新日: 2023-11-22)

• 主引用文献: Xu, X.,Li, Y.,Bharath, S.R.,Ozturk, M.B.,Bowler, M.W.,Loo, B.Z.L.,Tergaonkar, V.,Song, H.; Structural basis for reactivating the mutant TERT promoter by cooperative binding of p52 and ETS1.; Nat Commun, 9:3183-3183, 2018; PubMed: 30093619; DOI: 10.1038/s41467-018-05644-0

実験手法

X-RAY DIFFRACTION (2.99 Å)