5ZKB
Crystal structure of rationally thermostabilized M2 muscarinic acetylcholine receptor bound with AF-DX 384
Summary for 5ZKB
Entry DOI | 10.2210/pdb5zkb/pdb |
Related | 5ZK3 5ZK8 |
Descriptor | Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-[2-[(2S)-2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxidanylidene-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide (2 entities in total) |
Functional Keywords | gpcr crystallography, rationally thermostabilized mutant, membrane protein-inhibitor complex, membrane protein/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 47771.84 |
Authors | Suno, R.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Iwata, S.,Kobayashi, T. (deposition date: 2018-03-23, release date: 2018-11-21, Last modification date: 2022-03-23) |
Primary citation | Suno, R.,Lee, S.,Maeda, S.,Yasuda, S.,Yamashita, K.,Hirata, K.,Horita, S.,Tawaramoto, M.S.,Tsujimoto, H.,Murata, T.,Kinoshita, M.,Yamamoto, M.,Kobilka, B.K.,Vaidehi, N.,Iwata, S.,Kobayashi, T. Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor Nat. Chem. Biol., 14:1150-1158, 2018 Cited by PubMed: 30420692DOI: 10.1038/s41589-018-0152-y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.95 Å) |
Structure validation
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