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5ZG2

Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2

Summary for 5ZG2
Entry DOI10.2210/pdb5zg2/pdb
DescriptorGlutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid, 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide, ... (7 entities in total)
Functional Keywordsampa receptor ligand-binding domain, allosteric modulation complex, membrane protein, transport protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight60498.95
Authors
Sogabe, S.,Igaki, S.,Hirokawa, A.,Zama, Y.,Lane, W.,Snell, G. (deposition date: 2018-03-07, release date: 2019-01-16, Last modification date: 2023-11-22)
Primary citationKunugi, A.,Tanaka, M.,Suzuki, A.,Tajima, Y.,Suzuki, N.,Suzuki, M.,Nakamura, S.,Kuno, H.,Yokota, A.,Sogabe, S.,Kosugi, Y.,Awasaki, Y.,Kaku, T.,Kimura, H.
TAK-137, an AMPA-R potentiator with little agonistic effect, has a wide therapeutic window.
Neuropsychopharmacology, 44:961-970, 2019
Cited by
PubMed: 30209408
DOI: 10.1038/s41386-018-0213-7
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.25 Å)
Structure validation

217705

건을2024-03-27부터공개중

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