5ZG2
Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Glutamate receptor 2 | polymer | 263 | 29337.8 | 2 | UniProt (P42262) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Homo sapiens (Human) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2 |
2 | A, B | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 2 | Chemie (ZK1) | |||
3 | A | 9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxide | non-polymer | 316.4 | 1 | Chemie (9C0) | |||
4 | A, B | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
5 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
6 | B | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) | |||
7 | water | water | 18.0 | 652 | Chemie (HOH) |
Sequence modifications
A, B: 413 - 526 (UniProt: P42262)
A, B: 642 - 796 (UniProt: P42262)
PDB | External Database | Details |
---|---|---|
Gly 411 | - | expression tag |
Ser 412 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Lys 527 | - | linker |
Gly 641 | - | linker |
Thr 642 | Ser 652 | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 58675.7 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 1823.3 | |
All* | Total formula weight | 60499.0 |