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5ZG2

Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BGlutamate receptor 2polymer26329337.82UniProt (P42262)
Pfam (PF10613)
Pfam (PF00060)
Pfam (PF00497)
In PDB
Homo sapiens (Human)GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2
2A, B{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acidnon-polymer409.32Chemie (ZK1)
3A9-(4-~{tert}-butylphenyl)-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazine 2,2-dioxidenon-polymer316.41Chemie (9C0)
4A, BZINC IONnon-polymer65.45Chemie (ZN)
5A, BGLYCEROLnon-polymer92.12Chemie (GOL)
6BACETATE IONnon-polymer59.03Chemie (ACT)
7waterwater18.0652Chemie (HOH)
Sequence modifications
A, B: 413 - 526 (UniProt: P42262)
PDBExternal DatabaseDetails
Gly 411-expression tag
Ser 412-expression tag
A, B: 642 - 796 (UniProt: P42262)
PDBExternal DatabaseDetails
Lys 527-linker
Gly 641-linker
Thr 642Ser 652linker
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight58675.7
Non-Polymers*Number of molecules13
Total formula weight1823.3
All*Total formula weight60499.0
*Water molecules are not included.

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PDB entries from 2024-03-27

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