5ZG2
Crystal structure of the GluA2o LBD in complex with ZK200775 and Compound-2
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue ZK1 A 901 |
| Chain | Residue |
| A | GLU423 |
| A | THR707 |
| A | GLU726 |
| A | MET729 |
| A | TYR753 |
| A | HOH1034 |
| A | HOH1043 |
| A | HOH1056 |
| A | HOH1197 |
| A | TYR426 |
| A | TYR471 |
| A | PRO499 |
| A | LEU500 |
| A | THR501 |
| A | ARG506 |
| A | GLY674 |
| A | SER675 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue 9C0 A 902 |
| Chain | Residue |
| A | ILE502 |
| A | LYS514 |
| A | PRO515 |
| A | SER518 |
| A | SER750 |
| A | LYS751 |
| A | GLY752 |
| A | ASN775 |
| A | HOH1003 |
| A | HOH1006 |
| B | ILE502 |
| B | LYS514 |
| B | PRO515 |
| B | SER518 |
| B | SER750 |
| B | LYS751 |
| B | GLY752 |
| B | ASN775 |
| B | HOH1223 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 903 |
| Chain | Residue |
| A | GLU452 |
| A | HIS456 |
| A | LEU774 |
| A | GLN777 |
| A | HOH1001 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 904 |
| Chain | Residue |
| A | HIS433 |
| A | HOH1035 |
| A | HOH1218 |
| A | HOH1238 |
| B | HOH1044 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 905 |
| Chain | Residue |
| A | LYS470 |
| A | TYR471 |
| A | GLY472 |
| A | ALA473 |
| A | ASN482 |
| A | HOH1007 |
| A | HOH1217 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | binding site for residue ZK1 B 901 |
| Chain | Residue |
| B | GLU423 |
| B | TYR426 |
| B | TYR471 |
| B | PRO499 |
| B | LEU500 |
| B | THR501 |
| B | ARG506 |
| B | GLY674 |
| B | SER675 |
| B | THR707 |
| B | GLU726 |
| B | MET729 |
| B | TYR753 |
| B | HOH1067 |
| B | HOH1081 |
| B | HOH1085 |
| B | HOH1110 |
| B | HOH1117 |
| B | HOH1231 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue ZN B 902 |
| Chain | Residue |
| B | GLU437 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 903 |
| Chain | Residue |
| A | ASP672 |
| B | HIS433 |
| B | ACT907 |
| B | HOH1206 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue ZN B 904 |
| Chain | Residue |
| B | ASP475 |
| B | ACT905 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 905 |
| Chain | Residue |
| A | ARG441 |
| B | ASP475 |
| B | ASP477 |
| B | THR478 |
| B | ZN904 |
| B | HOH1087 |
| B | HOH1234 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue ACT B 906 |
| Chain | Residue |
| B | ARG474 |
| B | LYS479 |
| B | TYR490 |
| B | GLU665 |
| B | LYS720 |
| B | HOH1017 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue ACT B 907 |
| Chain | Residue |
| A | ASP672 |
| A | LYS677 |
| A | PHE703 |
| B | HIS433 |
| B | ZN903 |
| B | HOH1005 |
| B | HOH1055 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL B 908 |
| Chain | Residue |
| B | LYS470 |
| B | TYR471 |
| B | GLY472 |
| B | ALA473 |
| B | ASN482 |
| B | HOH1135 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20614889","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XHD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20614889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21531559","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XHD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3R7X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20614889","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21531559","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2XHD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"P19491","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"UniProtKB","id":"P19491","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
