5YPN

Crystal structure of NDM-1 bound to hydrolyzed meropenem representing an EI2 complex

Summary for 5YPN

• Entry DOI: 10.2210/pdb5ypn/pdb
• Descriptor: Metallo-beta-lactamase NDM-1, ZINC ION, (2~{S},3~{R},4~{S})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-(dimethylcarbamoy l)pyrrolidin-3-yl]sulfanyl-3-methyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, ... (5 entities in total)
• Functional Keywords: mdm-1, meropenem, ei2 complex, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 52520.36

Authors

Feng, H.,Liu, W.,Wang, D. (deposition date: 2017-11-02, release date: 2018-02-21, Last modification date: 2023-11-22)

• Primary citation: Feng, H.,Liu, X.,Wang, S.,Fleming, J.,Wang, D.C.,Liu, W.; The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis.; Nat Commun, 8:2242-2242, 2017; PubMed: 29269938; DOI: 10.1038/s41467-017-02339-w

Experimental method

X-RAY DIFFRACTION (2.12 Å)