5YPM

Crystal structure of NDM-1 bound to hydrolyzed meropenem representing an EI1 complex

Summary for 5YPM

Entry DOI	10.2210/pdb5ypm/pdb
Descriptor	Metallo-beta-lactamase NDM-1, ZINC ION, (2S,3R)-2-[(2S,3R)-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfan yl-3-methyl-2,3-dihydro-1H-pyrrole-5-carboxylic acid, ... (5 entities in total)
Functional Keywords	ndm-1, meropenem, ei1 complex, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	8
Total formula weight	209985.37
Authors	Feng, H.,Wang, D.,Liu, W. (deposition date: 2017-11-02, release date: 2018-02-21, Last modification date: 2023-11-22)
Primary citation	Feng, H.,Liu, X.,Wang, S.,Fleming, J.,Wang, D.C.,Liu, W. The mechanism of NDM-1-catalyzed carbapenem hydrolysis is distinct from that of penicillin or cephalosporin hydrolysis. Nat Commun, 8:2242-2242, 2017 Cited by PubMed: 29269938 DOI: 10.1038/s41467-017-02339-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation