5XIO

Crystal Structure of Cryptosporidium parvum Prolyl-tRNA Synthetase (CpPRS) in complex with Halofuginone

5XIO の概要

• エントリーDOI: 10.2210/pdb5xio/pdb
• 関連するPDBエントリー: 5XIF 5XIG 5XIH 5XII 5XIJ 5XIK 5XIL 5XIP 5XIQ
• 分子名称: Proline-tRNA synthetase class II aaRS (Ybak RNA binding domain plus tRNA synthetase), 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ZINC ION, ... (5 entities in total)
• 機能のキーワード: protein translation, prs, synthetase, inhibitor, infectious disease, ligase
• 由来する生物種: Cryptosporidium parvum
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117248.98

構造登録者

Jain, V.,Manickam, Y.,Sharma, A. (登録日: 2017-04-26, 公開日: 2018-03-07, 最終更新日: 2023-11-22)

• 主引用文献: Jain, V.,Yogavel, M.,Kikuchi, H.,Oshima, Y.,Hariguchi, N.,Matsumoto, M.,Goel, P.,Touquet, B.,Jumani, R.S.,Tacchini-Cottier, F.,Harlos, K.,Huston, C.D.,Hakimi, M.A.,Sharma, A.; Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis; Structure, 25:1495-1505.e6, 2017; PubMed: 28867614; DOI: 10.1016/j.str.2017.07.015

実験手法

X-RAY DIFFRACTION (2.46 Å)