5XIO
Crystal Structure of Cryptosporidium parvum Prolyl-tRNA Synthetase (CpPRS) in complex with Halofuginone
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| A | 0004827 | molecular_function | proline-tRNA ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| A | 0006433 | biological_process | prolyl-tRNA aminoacylation |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004812 | molecular_function | aminoacyl-tRNA ligase activity |
| B | 0004827 | molecular_function | proline-tRNA ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006418 | biological_process | tRNA aminoacylation for protein translation |
| B | 0006433 | biological_process | prolyl-tRNA aminoacylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue HFG A 801 |
| Chain | Residue |
| A | PHE307 |
| A | ANP803 |
| A | HOH901 |
| A | VAL311 |
| A | THR331 |
| A | GLU333 |
| A | ARG362 |
| A | TRP379 |
| A | PHE426 |
| A | HIS452 |
| A | GLY482 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 802 |
| Chain | Residue |
| A | CYS652 |
| A | CYS657 |
| A | CYS702 |
| A | CYS705 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | binding site for residue ANP A 803 |
| Chain | Residue |
| A | ARG362 |
| A | GLU364 |
| A | PHE371 |
| A | ILE372 |
| A | ARG373 |
| A | THR374 |
| A | PHE377 |
| A | GLN447 |
| A | THR450 |
| A | THR484 |
| A | ARG486 |
| A | HFG801 |
| A | HOH901 |
| A | HOH912 |
| A | HOH914 |
| A | HOH943 |
| A | HOH956 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 801 |
| Chain | Residue |
| B | CYS652 |
| B | CYS657 |
| B | CYS702 |
| B | CYS705 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue HFG B 802 |
| Chain | Residue |
| B | PHE307 |
| B | GLU310 |
| B | VAL311 |
| B | THR331 |
| B | GLU333 |
| B | ARG362 |
| B | TRP379 |
| B | PHE426 |
| B | THR450 |
| B | HIS452 |
| B | GLY482 |
| B | ANP803 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue ANP B 803 |
| Chain | Residue |
| B | ARG362 |
| B | GLU364 |
| B | ILE372 |
| B | ARG373 |
| B | THR374 |
| B | PHE377 |
| B | GLN447 |
| B | ALA449 |
| B | THR484 |
| B | ARG486 |
| B | HFG802 |
| B | HOH929 |
| B | HOH960 |
