5XIO
Crystal Structure of Cryptosporidium parvum Prolyl-tRNA Synthetase (CpPRS) in complex with Halofuginone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Proline-tRNA synthetase class II aaRS (Ybak RNA binding domain plus tRNA synthetase) | polymer | 498 | 57638.2 | 2 | UniProt (Q5CWN3) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) In PDB | Cryptosporidium parvum | |
| 2 | A, B | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one | non-polymer | 414.7 | 2 | Chemie (HFG) | |||
| 3 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | A, B | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
| 5 | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A, B: 225 - 719 (UniProt: Q5CWN3)
| PDB | External Database | Details |
|---|---|---|
| Gly 222 | - | expression tag |
| Ala 223 | - | expression tag |
| Met 224 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 115276.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1972.6 | |
| All* | Total formula weight | 117249.0 |
