5XHS
Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA
Summary for 5XHS
Entry DOI | 10.2210/pdb5xhs/pdb |
Descriptor | NAD-dependent protein deacylase sirtuin-5, mitochondrial, benzyl chlorocarbonate, (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, ... (6 entities in total) |
Functional Keywords | sirtuin, fluorogenic small molecule substrates, hydrolase |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion matrix. Isoform 1: Cytoplasm . Isoform 2: Mitochondrion : Q9NXA8 |
Total number of polymer chains | 1 |
Total formula weight | 32111.14 |
Authors | |
Primary citation | Wang, H.L.,Liu, S.,Yu, Z.J.,Wu, C.,Cheng, L.,Wang, Y.,Chen, K.,Zhou, S.,Chen, Q.,Yu, Y.,Li, G.B. Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design Rsc Adv, 7:36214-36222, 2017 Cited by DOI: 10.1039/C7RA05824APDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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