5XHS

Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA

5XHS の概要

• エントリーDOI: 10.2210/pdb5xhs/pdb
• 分子名称: NAD-dependent protein deacylase sirtuin-5, mitochondrial, benzyl chlorocarbonate, (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, ... (6 entities in total)
• 機能のキーワード: sirtuin, fluorogenic small molecule substrates, hydrolase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion matrix. Isoform 1: Cytoplasm . Isoform 2: Mitochondrion : Q9NXA8
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32111.14

構造登録者

Yu, Y.,Li, B.,Chen, Q. (登録日: 2017-04-24, 公開日: 2018-05-02, 最終更新日: 2024-03-27)

• 主引用文献: Wang, H.L.,Liu, S.,Yu, Z.J.,Wu, C.,Cheng, L.,Wang, Y.,Chen, K.,Zhou, S.,Chen, Q.,Yu, Y.,Li, G.B.; Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design; Rsc Adv, 7:36214-36222, 2017; DOI: 10.1039/C7RA05824A

実験手法

X-RAY DIFFRACTION (2.19 Å)