Crystal structure of Mycobacterium tuberculosis methionyl-tRNA synthetase bound by methionyl-adenylate (Met-AMP)

Summary for 5XET

DescriptorMethionine--tRNA ligase, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] (2S)-2-azanyl-4-methylsulfanyl-butanoate, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordssynthetase, aminoacyl-trna synthetase, complex, atp, ligase
Biological sourceMycobacterium tuberculosis H37Ra
Total number of polymer chains1
Total molecular weight60081.83
Wang, W.,Qin, B.,Wojdyla, J.A.,Wang, M.,Gao, X.,Cui, S. (deposition date: 2017-04-06, release date: 2018-07-11, Last modification date: 2018-08-01)
Primary citation
Wang, W.,Qin, B.,Wojdyla, J.A.,Wang, M.,Gao, X.,Cui, S.
Structural characterization of free-state and product-stateMycobacterium tuberculosismethionyl-tRNA synthetase reveals an induced-fit ligand-recognition mechanism.
IUCrJ, 5:478-490, 2018
PubMed: 30002848 (PDB entries with the same primary citation)
DOI: 10.1107/S2052252518008217
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.252900.2%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution