5XET

Crystal structure of Mycobacterium tuberculosis methionyl-tRNA synthetase bound by methionyl-adenylate (Met-AMP)

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000166	molecular_function	nucleotide binding
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004825	molecular_function	methionine-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006412	biological_process	translation
C	0006418	biological_process	tRNA aminoacylation for protein translation
C	0006431	biological_process	methionyl-tRNA aminoacylation
C	0016874	molecular_function	ligase activity
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue ME8 C 601

Chain	Residue
C	ALA9
C	TRP228
C	ALA231
C	TYR235
C	GLY261
C	ASP263
C	ILE264
C	HIS290
C	GLY291
C	PHE292
C	LEU293
C	ILE10
C	HOH721
C	HOH762
C	HOH811
C	ALA11
C	TYR12
C	HIS18
C	GLY20
C	HIS21
C	GLU24
C	ASP49

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site_id	AC2
Number of Residues	4
Details	binding site for residue EDO C 602

Chain	Residue
C	ARG33
C	ASN85
C	HOH789
C	HOH816

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site_id	AC3
Number of Residues	3
Details	binding site for residue MG C 603

Chain	Residue
C	VAL19
C	SER301
C	VAL308

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site_id	AC4
Number of Residues	2
Details	binding site for residue MG C 604

Chain	Residue
C	ARG397
C	HOH788

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site_id	AC5
Number of Residues	4
Details	binding site for residue MG C 605

Chain	Residue
C	TYR23
C	LEU326
C	VAL330
C	PHE332

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site_id	AC6
Number of Residues	3
Details	binding site for residue MG C 606

Chain	Residue
C	ARG328
C	HOH751
C	HOH855

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site_id	AC7
Number of Residues	1
Details	binding site for residue MG C 607

Chain	Residue
C	ARG446

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Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	10
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..NAaPHVGHA

Chain	Residue	Details
C	PRO13-ALA22

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