5X8X

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.

Summary for 5X8X

• Entry DOI: 10.2210/pdb5x8x/pdb
• Related: 5X8Q 5X8S 5X8U 5X8W
• Descriptor: Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, (3R,4R)-4-[4-cyclopropyl-5-[3-(2-methylpropyl)cyclobutyl]-1,2,4-triazol-3-yl]-N-(2,4-dimethylphenyl)-1-ethanoyl-pyrrolidine-3-carboxamide, ... (4 entities in total)
• Functional Keywords: inhibitor, ternary complex, nuclear receptor, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 131327.77

Authors

Noguchi, M.,Nomura, A.,Murase, K.,Doi, S.,Yamaguchi, K.,Adachi, T. (deposition date: 2017-03-03, release date: 2017-06-07, Last modification date: 2023-11-22)

• Primary citation: Noguchi, M.,Nomura, A.,Murase, K.,Doi, S.,Yamaguchi, K.,Hirata, K.,Shiozaki, M.,Hirashima, S.,Kotoku, M.,Yamaguchi, T.,Katsuda, Y.,Steensma, R.,Li, X.,Tao, H.,Tse, B.,Fenn, M.,Babine, R.,Bradley, E.,Crowe, P.,Thacher, S.,Adachi, T.,Kamada, M.; Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment; Genes Cells, 22:535-551, 2017; PubMed: 28493531; DOI: 10.1111/gtc.12494

Experimental method

X-RAY DIFFRACTION (2.6 Å)