5X8Q

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.

Summary for 5X8Q

• Entry DOI: 10.2210/pdb5x8q/pdb
• Related: 5X8S 5X8U 5X8W 5X8X
• Descriptor: Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2, (1R,2S,4S,5'R,6R,7S,8R,9S,10R,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosane-6,2'-oxane]-10,16-diol, ... (4 entities in total)
• Functional Keywords: inhibitor, ternary complex, nuclear receptor, transferase-ihibitor complex, transferase/ihibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P51449 Q9Y618
• Total number of polymer chains: 8
• Total formula weight: 131147.74

Authors

Noguchi, M.,Nomura, A.,Murase, K.,Doi, S.,Yamaguchi, K.,Adachi, T. (deposition date: 2017-03-03, release date: 2017-06-07, Last modification date: 2023-11-22)

• Primary citation: Noguchi, M.,Nomura, A.,Murase, K.,Doi, S.,Yamaguchi, K.,Hirata, K.,Shiozaki, M.,Hirashima, S.,Kotoku, M.,Yamaguchi, T.,Katsuda, Y.,Steensma, R.,Li, X.,Tao, H.,Tse, B.,Fenn, M.,Babine, R.,Bradley, E.,Crowe, P.,Thacher, S.,Adachi, T.,Kamada, M.; Ternary complex of human ROR gamma ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment; Genes Cells, 22:535-551, 2017; PubMed: 28493531; DOI: 10.1111/gtc.12494

Experimental method

X-RAY DIFFRACTION (2.2 Å)