5X8Q

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With rockogenin.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0004879	molecular_function	nuclear receptor activity
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
G	0003677	molecular_function	DNA binding
G	0004879	molecular_function	nuclear receptor activity
G	0005634	cellular_component	nucleus
G	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue 82R A 9000

Chain	Residue
A	CYS285
A	GLN286
A	CYS320
A	VAL361
A	ARG364
A	PHE377
A	PHE378
A	PHE388

---

site_id	AC2
Number of Residues	10
Details	binding site for residue 82R C 9000

Chain	Residue
C	GLN286
C	HIS323
C	ALA327
C	ARG364
C	ARG367
C	PHE377
C	PHE378
C	PHE388
C	ILE397
C	CYS285

---

site_id	AC3
Number of Residues	9
Details	binding site for residue 82R E 9000

Chain	Residue
E	CYS285
E	GLN286
E	HIS323
E	LEU324
E	ALA327
E	ARG364
E	PHE377
E	PHE378
E	PHE388

---

site_id	AC4
Number of Residues	11
Details	binding site for residue 82R G 9000

Chain	Residue
G	CYS285
G	GLN286
G	CYS320
G	LEU324
G	VAL361
G	ARG364
G	ARG367
G	PHE377
G	PHE388
G	ILE397
G	ILE400

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Motif: {"description":"CORNR box of ID2","evidences":[{"source":"UniProtKB","id":"Q60974","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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