5X8X

Crystal Structure of the mutant Human ROR gamma Ligand Binding Domain With Compound A.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
C	0003677	molecular_function	DNA binding
C	0004879	molecular_function	nuclear receptor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
E	0003677	molecular_function	DNA binding
E	0004879	molecular_function	nuclear receptor activity
E	0005634	cellular_component	nucleus
E	0006355	biological_process	regulation of DNA-templated transcription
G	0003677	molecular_function	DNA binding
G	0004879	molecular_function	nuclear receptor activity
G	0005634	cellular_component	nucleus
G	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue 82O A 9000

Chain	Residue
A	GLN286
A	PHE388
A	PHE401
A	HIS323
A	ALA327
A	VAL361
A	MET365
A	ALA368
A	VAL376
A	PHE377
A	PHE378

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site_id	AC2
Number of Residues	10
Details	binding site for residue 82O C 9000

Chain	Residue
C	GLN286
C	LEU287
C	HIS323
C	ALA327
C	MET365
C	ALA368
C	VAL376
C	PHE377
C	ILE397
C	ILE400

---

site_id	AC3
Number of Residues	8
Details	binding site for residue 82O E 9000

Chain	Residue
E	HIS323
E	ALA327
E	MET365
E	ALA368
E	VAL376
E	PHE377
E	PHE378
E	HOH9104

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site_id	AC4
Number of Residues	9
Details	binding site for residue 82O G 9000

Chain	Residue
G	GLN286
G	HIS323
G	ALA327
G	MET365
G	ALA368
G	VAL376
G	PHE377
G	PHE378
G	PHE401

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