5WZZ

The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation

Summary for 5WZZ

Entry DOI	10.2210/pdb5wzz/pdb
Descriptor	E3 ubiquitin-protein ligase SIAH1, Axin-1, ZINC ION, ... (4 entities in total)
Functional Keywords	protein complex, wnt pathway, ligase
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm: Q8IUQ4 O15169
Total number of polymer chains	8
Total formula weight	96052.73
Authors	Ji, L.,Jiang, B.,Jiang, X.,Charlat, O.,Chen, A.,Mickanin, C.,Bauer, A.,Xu, W.,Yan, X.-X.,Cong, F. (deposition date: 2017-01-19, release date: 2017-08-16, Last modification date: 2023-11-22)
Primary citation	Ji, L.,Jiang, B.,Jiang, X.,Charlat, O.,Chen, A.,Mickanin, C.,Bauer, A.,Xu, W.,Yan, X.-X.,Cong, F. The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation Genes Dev., 31:904-915, 2017 Cited by PubMed: 28546513 DOI: 10.1101/gad.300053.117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.103 Å)

Structure validation