5WZZ

The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation

Summary for 5WZZ

DescriptorE3 ubiquitin-protein ligase SIAH1, Axin-1, ZINC ION, ... (4 entities in total)
Functional Keywordsprotein complex, wnt pathway, ligase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm Q8IUQ4 O15169
Total number of polymer chains8
Total molecular weight96052.73
Authors
Ji, L.,Jiang, B.,Jiang, X.,Charlat, O.,Chen, A.,Mickanin, C.,Bauer, A.,Xu, W.,Yan, X.-X.,Cong, F. (deposition date: 2017-01-19, release date: 2017-08-16, Last modification date: 2017-08-30)
Primary citation
Ji, L.,Jiang, B.,Jiang, X.,Charlat, O.,Chen, A.,Mickanin, C.,Bauer, A.,Xu, W.,Yan, X.-X.,Cong, F.
The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation
Genes Dev., 31:904-915, 2017
PubMed: 28546513 (PDB entries with the same primary citation)
DOI: 10.1101/gad.300053.117
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.103 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.215100 2.6% 8.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171588
PDB entries from 2020-11-25