5WZZ
The SIAH E3 ubiquitin ligases promote Wnt/ beta-catenin signaling through mediating Wnt-induced Axin degradation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | E3 ubiquitin-protein ligase SIAH1 | polymer | 190 | 21409.5 | 4 | UniProt (Q8IUQ4) Pfam (PF21361) Pfam (PF03145) In PDB | Homo sapiens (Human) | Seven in absentia homolog 1,Siah-1,Siah-1a |
| 2 | E, F, G, H | Axin-1 | polymer | 20 | 2472.9 | 4 | UniProt (O15169) In PDB | Homo sapiens (Human) | Axis inhibition protein 1,hAxin |
| 3 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 4 | water | water | 18.0 | 216 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 95529.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 523.3 | |
| All* | Total formula weight | 96052.7 |
