5WLW
Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A.
Summary for 5WLW
Entry DOI | 10.2210/pdb5wlw/pdb |
Related | 5WGB 5WKP |
Descriptor | Cysteine desulfurase, mitochondrial, LYR motif-containing protein 4, Acyl carrier protein, ... (7 entities in total) |
Functional Keywords | human mitochondrial cysteine desulfurse lyr motif containing protein 4 iron-sulfur cluster scaffold protein iscu1 with zn in the active site acyl carrier protein 1 (e.coli), transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: Q9Y697 Mitochondrion: Q9HD34 Cytoplasm : B7MJ81 Isoform 1: Mitochondrion . Isoform 2: Cytoplasm: Q9H1K1 |
Total number of polymer chains | 8 |
Total formula weight | 163100.69 |
Authors | Boniecki, M.T.,Cygler, M. (deposition date: 2017-07-27, release date: 2017-11-15, Last modification date: 2023-10-04) |
Primary citation | Boniecki, M.T.,Freibert, S.A.,Muhlenhoff, U.,Lill, R.,Cygler, M. Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex. Nat Commun, 8:1287-1287, 2017 Cited by PubMed: 29097656DOI: 10.1038/s41467-017-01497-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.317 Å) |
Structure validation
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