5WLW

Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine Loop within ISCU1 active site, coordinating Zn ion. Complexed with human ISD11 and E. coli ACP1 at 3.3A.

5WLW の概要

• エントリーDOI: 10.2210/pdb5wlw/pdb
• 関連するPDBエントリー: 5WGB 5WKP
• 分子名称: Cysteine desulfurase, mitochondrial, LYR motif-containing protein 4, Acyl carrier protein, ... (7 entities in total)
• 機能のキーワード: human mitochondrial cysteine desulfurse lyr motif containing protein 4 iron-sulfur cluster scaffold protein iscu1 with zn in the active site acyl carrier protein 1 (e.coli), transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: Q9Y697; Mitochondrion: Q9HD34; Cytoplasm : B7MJ81; Isoform 1: Mitochondrion . Isoform 2: Cytoplasm: Q9H1K1
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 163100.69

構造登録者

Boniecki, M.T.,Cygler, M. (登録日: 2017-07-27, 公開日: 2017-11-15, 最終更新日: 2023-10-04)

• 主引用文献: Boniecki, M.T.,Freibert, S.A.,Muhlenhoff, U.,Lill, R.,Cygler, M.; Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.; Nat Commun, 8:1287-1287, 2017; PubMed: 29097656; DOI: 10.1038/s41467-017-01497-1

実験手法

X-RAY DIFFRACTION (3.317 Å)