5WLO

a novel 13-ring macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands

Summary for 5WLO

• Entry DOI: 10.2210/pdb5wlo/pdb
• Related: 3I6O
• Descriptor: Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: hiv protease, macrocyclic inhibitors, p1'- p2' ligands, drug resistance, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22463.50

Authors

Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (deposition date: 2017-07-27, release date: 2017-10-11, Last modification date: 2023-10-04)

• Primary citation: Ghosh, A.K.,Sean Fyvie, W.,Brindisi, M.,Steffey, M.,Agniswamy, J.,Wang, Y.F.,Aoki, M.,Amano, M.,Weber, I.T.,Mitsuya, H.; Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands.; Bioorg. Med. Chem. Lett., 27:4925-4931, 2017; PubMed: 28958624; DOI: 10.1016/j.bmcl.2017.09.003

Experimental method

X-RAY DIFFRACTION (1.27 Å)