5WLO
a novel 13-ring macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands
Summary for 5WLO
Entry DOI | 10.2210/pdb5wlo/pdb |
Related | 3I6O |
Descriptor | Protease, SODIUM ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | hiv protease, macrocyclic inhibitors, p1'- p2' ligands, drug resistance, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22463.50 |
Authors | Wang, Y.-F.,Agniswamy, J.,Weber, I.T. (deposition date: 2017-07-27, release date: 2017-10-11, Last modification date: 2023-10-04) |
Primary citation | Ghosh, A.K.,Sean Fyvie, W.,Brindisi, M.,Steffey, M.,Agniswamy, J.,Wang, Y.F.,Aoki, M.,Amano, M.,Weber, I.T.,Mitsuya, H. Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands. Bioorg. Med. Chem. Lett., 27:4925-4931, 2017 Cited by PubMed: 28958624DOI: 10.1016/j.bmcl.2017.09.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.27 Å) |
Structure validation
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