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5WLO

a novel 13-ring macrocyclic HIV-1 protease inhibitors involving the P1'-P2' ligands

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BProteasepolymer9910740.72UniProt (Q5RZ08)
Pfam (PF00077)
UniProt (by SIFTS) (Q72498)
In PDB
Human immunodeficiency virus 1
2ASODIUM IONnon-polymer23.01Chemie (NA)
3A, BCHLORIDE IONnon-polymer35.55Chemie (CL)
4B(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-3-hydroxy-4-[(7E)-13-methoxy-1,1-dioxo-1,4,5,6,9,11-hexahydro-10,1lambda~6~,2-benzoxathiazacyclotridecin-2(3H)-yl]-1-phenylbutan-2-yl}carbamatenon-polymer630.71Chemie (GR7)
5BGLYCEROLnon-polymer92.11Chemie (GOL)
6BACETATE IONnon-polymer59.01Chemie (ACT)
7waterwater18.0191Chemie (HOH)
Sequence modifications
A, B: 1 - 99 (UniProt: Q5RZ08)
PDBExternal DatabaseDetails
Lys 7Gln 7engineered mutation
Ile 33Leu 33engineered mutation
Ile 63Leu 63engineered mutation
Ala 67Cys 67engineered mutation
Ala 95Cys 95engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight21481.4
Non-Polymers*Number of molecules9
Total formula weight982.1
All*Total formula weight22463.5
*Water molecules are not included.

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PDB entries from 2024-07-17

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