5W4V
Structure of RORgt bound to a tertiary alcohol
Summary for 5W4V
Entry DOI | 10.2210/pdb5w4v/pdb |
Related | 5W4R |
Descriptor | Nuclear receptor ROR-gamma, (R)-(4-chloro-2-methoxy-3-{[4-(1H-pyrazol-1-yl)phenyl]methyl}quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)[6-(trifluoromethyl)pyridin-3-yl]methanol (3 entities in total) |
Functional Keywords | rorgt nuclear hormone receptor, nuclear protein |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : P51449 |
Total number of polymer chains | 6 |
Total formula weight | 150680.13 |
Authors | Spurlino, J.,Hars, U. (deposition date: 2017-06-13, release date: 2017-12-27, Last modification date: 2023-10-04) |
Primary citation | Barbay, J.K.,Cummings, M.D.,Abad, M.,Castro, G.,Kreutter, K.D.,Kummer, D.A.,Maharoof, U.,Milligan, C.,Nishimura, R.,Pierce, J.,Schalk-Hihi, C.,Spurlino, J.,Tanis, V.M.,Urbanski, M.,Venkatesan, H.,Wang, A.,Woods, C.,Wolin, R.,Xue, X.,Edwards, J.P.,Fourie, A.M.,Leonard, K. 6-Substituted quinolines as ROR gamma t inverse agonists. Bioorg. Med. Chem. Lett., 27:5277-5283, 2017 Cited by PubMed: 29079472DOI: 10.1016/j.bmcl.2017.10.027 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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