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5VUX

Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((4-(Dimethylamino)benzyl)amino)methyl)quinolin-2-amine

5VUX の概要
エントリーDOI10.2210/pdb5vux/pdb
関連するPDBエントリー5VUI 5VUJ 5VUK 5VUL 5VUM 5VUN 5VUO 5VUP 5VUQ 5VUR 5VUS 5VUT 5VUU 5VUV 5VUW 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 5VV6 5VV7 5VV8 5VV9 5VVA 5VVB 5VVC 5VVD 5VVG 5VVN
分子名称Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
機能のキーワードnitric oxide synthase, inhibitor complex, heme enzyme, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor
由来する生物種Homo sapiens (Human)
タンパク質・核酸の鎖数2
化学式量合計99962.68
構造登録者
Huiying, L.,Thomas, L.P. (登録日: 2017-05-19, 公開日: 2017-08-23, 最終更新日: 2023-10-04)
主引用文献Pensa, A.V.,Cinelli, M.A.,Li, H.,Chreifi, G.,Mukherjee, P.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
J. Med. Chem., 60:7146-7165, 2017
Cited by
PubMed: 28776992
DOI: 10.1021/acs.jmedchem.7b00835
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.3 Å)
構造検証レポート
Validation report summary of 5vux
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-06-12に公開中

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