5VV2
Structure of human neuronal nitric oxide synthase heme domain in complex with 7-(((3-(5-Fluoropyridin-3-yl)propyl)amino)methyl)quinolin-2-amine
Summary for 5VV2
Entry DOI | 10.2210/pdb5vv2/pdb |
Related | 5VUI 5VUJ 5VUK 5VUL 5VUM 5VUN 5VUO 5VUP 5VUQ 5VUR 5VUS 5VUT 5VUU 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV3 5VV4 5VV5 5VV6 5VV7 5VV8 5VV9 5VVA 5VVB 5VVC 5VVD 5VVG 5VVN |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total) |
Functional Keywords | nitric oxide synthase, inhibitor complex, heme enzyme, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 99970.61 |
Authors | Huiying, L.,Thomas, L.P. (deposition date: 2017-05-19, release date: 2017-08-23, Last modification date: 2023-10-04) |
Primary citation | Pensa, A.V.,Cinelli, M.A.,Li, H.,Chreifi, G.,Mukherjee, P.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. J. Med. Chem., 60:7146-7165, 2017 Cited by PubMed: 28776992DOI: 10.1021/acs.jmedchem.7b00835 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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