5VUT
Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)benzonitrile
Summary for 5VUT
Entry DOI | 10.2210/pdb5vut/pdb |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | nitric oxide synthase, inhibitor complex, heme enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Rattus norvegicus (Rat) |
Total number of polymer chains | 2 |
Total formula weight | 100156.82 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2017-05-19, release date: 2017-08-16, Last modification date: 2023-10-04) |
Primary citation | Pensa, A.V.,Cinelli, M.A.,Li, H.,Chreifi, G.,Mukherjee, P.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B. Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors. J. Med. Chem., 60:7146-7165, 2017 Cited by PubMed: 28776992DOI: 10.1021/acs.jmedchem.7b00835 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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