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5VV5

Structure of human neuronal nitric oxide synthase heme domain in complex with 4-(2-(((2-Amino-4-methylquinolin-7-yl)methyl)amino)ethyl)-2-methylbenzonitrile

Summary for 5VV5
Entry DOI10.2210/pdb5vv5/pdb
Related5VUV 5VUW 5VUX 5VUY 5VUZ 5VV1 5VV2 5VV3 5VV4 5VVB
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (6 entities in total)
Functional Keywordsnitric oxide synthase inhibitor complex, heme enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight100010.72
Authors
Li, H.,Poulos, T.L. (deposition date: 2017-05-19, release date: 2017-08-16, Last modification date: 2023-10-04)
Primary citationPensa, A.V.,Cinelli, M.A.,Li, H.,Chreifi, G.,Mukherjee, P.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.
J. Med. Chem., 60:7146-7165, 2017
Cited by
PubMed: 28776992
DOI: 10.1021/acs.jmedchem.7b00835
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.15 Å)
Structure validation

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